Last update
3/19/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
250 mg
60%
Top Medical Research Studies
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
7
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
Read More
7
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Read More
Most Useful Reviews
9
Reduced irritability
This magnesium supplement works well for me. I take it once at night, and it has significantly reduced my fatigue and improved my sleep. I'm less irritable now.
Read More
7.5
Stress management
1 people found this helpful
This magnesium, taken with Vitamin B6 for a month in spring and autumn, has helped me manage stress better. Though fatigue persists in autumn, I feel less nervous than usual. For the price, it’s excellent, and I plan to keep purchasing it.
Read More
7.5
Improved sleep quality
Good quality, size, taste, and packaging. Magnesium aids calcium and vitamin B assimilation. It alleviates muscle fatigue and enhances sleep while positively impacting joints. A necessary mineral for overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.6
- All Researches
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
7
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Read More
7
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
Read More
7
Magnesium shows promise for CFS
We explored the effects of magnesium on chronic fatigue syndrome (CFS), a condition marked by extended periods of debilitating fatigue. While there’s no definitive therapy established for CFS, our review of clinical trials reveals that magnesium treatment has shown promise, enhancing the well-being of some patients.
Other treatments like acyclovir have proven ineffective, and although intravenous immunoglobulin therapy shows potential, its results remain debated. We recognize that restoring immune function may be a piece of the puzzle, but overall, the effectiveness of magnesium for treating CFS symptoms is yet to be firmly established.
Other treatments like acyclovir have proven ineffective, and although intravenous immunoglobulin therapy shows potential, its results remain debated. We recognize that restoring immune function may be a piece of the puzzle, but overall, the effectiveness of magnesium for treating CFS symptoms is yet to be firmly established.
Read More
4
We systematically reviewed randomized controlled trials on complementary and alternative medicine (CAM) treatments for chronic fatigue syndrome (CFS).
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced irritability
This magnesium supplement works well for me. I take it once at night, and it has significantly reduced my fatigue and improved my sleep. I'm less irritable now.
Read More
7.5
Stress management
1 people found this helpful
This magnesium, taken with Vitamin B6 for a month in spring and autumn, has helped me manage stress better. Though fatigue persists in autumn, I feel less nervous than usual. For the price, it’s excellent, and I plan to keep purchasing it.
Read More
7.5
Improved sleep quality
Good quality, size, taste, and packaging. Magnesium aids calcium and vitamin B assimilation. It alleviates muscle fatigue and enhances sleep while positively impacting joints. A necessary mineral for overall health.
Read More
7.5
Calmness achieved
Peace and tranquility! I regularly take one capsule, and it has made life more pleasant. Fatigue has vanished, and I prefer this affordable option over more expensive brands. Highly recommend it!
Read More
Frequently Asked Questions
7.5
Stress management
1 people found this helpful
This magnesium, taken with Vitamin B6 for a month in spring and autumn, has helped me manage stress better. Though fatigue persists in autumn, I feel less nervous than usual. For the price, it’s excellent, and I plan to keep purchasing it.
7.5
Improved sleep quality
Good quality, size, taste, and packaging. Magnesium aids calcium and vitamin B assimilation. It alleviates muscle fatigue and enhances sleep while positively impacting joints. A necessary mineral for overall health.
9
Reduced irritability
This magnesium supplement works well for me. I take it once at night, and it has significantly reduced my fatigue and improved my sleep. I'm less irritable now.
4
We systematically reviewed randomized controlled trials on complementary and alternative medicine (CAM) treatments for chronic fatigue syndrome (CFS).
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
7
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
7
Magnesium shows promise for CFS
We explored the effects of magnesium on chronic fatigue syndrome (CFS), a condition marked by extended periods of debilitating fatigue. While there’s no definitive therapy established for CFS, our review of clinical trials reveals that magnesium treatment has shown promise, enhancing the well-being of some patients.
Other treatments like acyclovir have proven ineffective, and although intravenous immunoglobulin therapy shows potential, its results remain debated. We recognize that restoring immune function may be a piece of the puzzle, but overall, the effectiveness of magnesium for treating CFS symptoms is yet to be firmly established.
Other treatments like acyclovir have proven ineffective, and although intravenous immunoglobulin therapy shows potential, its results remain debated. We recognize that restoring immune function may be a piece of the puzzle, but overall, the effectiveness of magnesium for treating CFS symptoms is yet to be firmly established.
References
- Alraek T, Lee MS, Choi TY, Cao H, Liu J. Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review. BMC Complement Altern Med. 2011;11:87. 10.1186/1472-6882-11-87
- Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Nève J, et al. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr. 2000;19:374.
- Takahashi H, Imai K, Katanuma A, Sugaya T, Hisano K, et al. [A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate]. Arerugi. 1992;41:1605.
- Uchida A. [Therapy of chronic fatigue syndrome]. Nihon Rinsho. 1992;50:2679.
- Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991;337:757.
Data last updated:
